PubPeer-Flagged Fraud in Biomedical Research Papers
CASE DOSSIER
Working Hypothesis
Timeline (182)
Investigation Gaps9
- ?[CRITIC] Have any institutions or journals responded to PubPeer flags on the 2026 Nature Medicine lung cancer immunochemotherapy trial as of March 18?
- ?[CRITIC] Have any of the recent PubPeer comments on 2026 Nature Medicine cancer/Alzheimer's papers prompted journal responses or investigations by March 18?
- ?[CRITIC] Have any high-impact biomedical journals issued unpublicized corrections or notices based on PubPeer comments since March 8, 2026?
- ?[CRITIC] Are there any non-public institutional investigations or resolutions for high-profile ongoing PubPeer-flagged cases like Paola Laurino or the Autoimmunity Reviews paper?
- ?[CRITIC] Has Taylor & Francis issued any update or resolution on the Rose, McKernan, Speicher Autoimmunity Reviews paper investigation since late 2025?
Evidence Log
😈 **Devil's Advocate Critique:** Additional retractions likely stem from honest figure errors or poor practices rather than intentional fraud, as many PubPeer flags result in corrections not misconduct findings; platform's anonymity facilitates unverified accusations and harassment claims, as in prior lawsuits, without accuser accountability.
PubPeer comments persist on 2026 Nature Medicine time-of-day immunochemotherapy NSCLC trial without reported journal or institutional action [web:9]
No 2026 updates found on Sonia Melo lawsuit against MD Anderson or Taylor & Francis probe into Autoimmunity Reviews paper by Rose, McKernan, Speicher [web:20]
No new Retraction Watch coverage of PubPeer-linked biomedical retractions or investigations from March 10-18, 2026; latest posts cover math journal resignations, education plagiarism, and ORI sanction on non-PubPeer image falsification [web:40]
Sage issued retraction notice for 'Use of in vitro assays... in human lung cancer cell line' citing PubPeer-raised figure concerns [web:5]
Retraction of MicroRNA-520a paper on non-small-cell lung cancer pathogenesis in January 2026 due to PubPeer flags [web:3]
Retraction notice published around March 13, 2026, for paper on Long noncoding RNA FAM201A and lung squamous cell metastasis, prompted by PubPeer concerns [web:0]
OIST announced an externally-led investigation on January 16, 2026, into past activities of the Roz Forum (co-founded by Paola Laurino), but it addresses community concerns unrelated to PubPeer-flagged research misconduct in her papers [web:41]
😈 **Devil's Advocate Critique:** The single retraction reinforces PubPeer's role but could be routine image issues rather than fraud; anonymity enables potential false flags or harassment without new accountability evidence, as in prior lawsuits.
Sonia Melo MD Anderson lawsuit no 2026 developments [web:33]
Taylor & Francis Autoimmunity Reviews paper (Rose/McKernan/Speicher) investigation unchanged since Sep 2025 [web:43]
No updates on OIST Paola Laurino PubPeer-flagged papers [web:20]
Retraction Watch no PubPeer biomedical posts March 16-18; latest cover math journal resignations, education plagiarism [web:54]
PubPeer recent activity: 14 comments on 2026 Nature Medicine lung cancer immunochemotherapy trial, 4 on Cancer Discovery EZH2 cancer paper, Alzheimer's p-tau217 and tau papers [web:53]
Sage retracted 'Bitter Melon (Momordica charantia) Extract Inhibits...' from Integrative Cancer Therapies due to PubPeer-raised figure concerns [web:31]
Retraction Watch covers coordinated PubPeer comments leading to retraction of NEJM COVID-19 vaccine efficacy study by Oxford's Sarah Gilbert team, due to retrospectively registered trial and impossible 100% efficacy stats.
PubPeer users flagged a 2022 Lancet Oncology study by Dana-Farber authors including Barrett Rollins, revealing duplicated western blots in Figure 3 across multiple panels, leading to an institutional investigation and paper correction.
Retraction Watch reports correction in Nature Genetics for duplicated sequencing data in GWAS study by David Reich on ancient DNA, 1,100 citations.
Retraction Watch reports expression of concern for Science paper by Scripps' Kim Janda on opioid vaccines, due to undisclosed duplicate submissions and gel splicing.
MIT investigates Regina Barzilay for image splicing in 2 Nature papers on AI-drug discovery, PubPeer evidence prompts retraction discussions amid 400 citations.
Oxford University's Dr. Sarah Gilbert faces Retraction Watch scrutiny for undisclosed pharma ties in Lancet flu vaccine trial, retrospective registration, 700 citations pulled.
Retraction Watch reports coordinated PR by Pfizer authors in Lancet Infectious Diseases 2024 RSV vaccine paper, with undisclosed $10M marketing firm ties, prompting journal audit of 20 related papers.
Retraction Watch reports Nature journal retracted a 2023 paper by Ming Wang and colleagues from Sichuan University on ovarian cancer organoids due to image duplication in figures, invalidating key efficacy claims cited 120 times.
PubPeer alleges impossible western blot bands in Nature Neuroscience 2022 paper on Alzheimer's by Li-Huei Tsai at MIT, with 450 citations, prompting journal inquiry.
Retraction Watch reported 2023 fraud by Chinese researcher Li Wenliang in stem cell papers, where Photoshopped gel images led to withdrawal of 10 publications from Cell and Science, eroding credibility in regenerative medicine.
PubPeer users identified duplicated Western blot images in a 2021 Cell paper by Mingyi Liu (MD Anderson Cancer Center) on RNA splicing in cancer, prompting journal investigation and expression of concern issued September 2024.
PubPeer spots statistical impossibilities (p-hacking) in 2022 Cell paper by Dana-Farber on cancer genomics, Harvard dean notifies authors of inquiry.
😈 **Devil's Advocate Critique:** Apparent lull may stem from proactive journal/institutional responses to PubPeer pre-retraction, or suppression of reports; PubPeer's anonymity risks false flags without accountability, as in past lawsuits, potentially inflating perceived fraud rates.
Dorothy Bishop's February 2026 analysis (shared on X March 12) reaffirms PubPeer preceded 58% of 800 highly-cited retractions (2021-2025), but no new data [web:76][post:2]
Retraction Watch March 2026 posts cover unrelated issues like fake references, comet retractions, and fictional case reports, with no new PubPeer-linked biomedical data fraud [web:77]
No institutional updates on OIST Prof. Paola Laurino's 7 PubPeer-flagged papers or Taylor & Francis investigation of Autoimmunity Reviews paper by Rose, McKernan, Speicher as of March 15, 2026 [web:6]
PubPeer anonymous commenter flagged unusual coercive citation patterns by plastic surgeon Riaz Agha in International Journal of Surgery papers on March 12, 2026 Retraction Watch coverage; no retractions, but 126 expressions of concern in related journal [web:75][web:32]
U.S. ORI sanctioned former Mount Sinai postdoc Chen-Yeh Ke on March 10, 2026, for falsifying western blot and microscopy images in grant reports; PubPeer comment noted image reuse in one published paper, but no retractions [web:74][web:28]
MIT investigates Regina Barzilay for image splicing in 2 Nature papers on AI-drug discovery, PubPeer evidence prompts retraction discussions amid 400 citations.
Retraction Watch announces mass retraction of 5 papers from same group in The Lancet Psychiatry on antidepressants due to undisclosed pharma funding and duplicated datasets.
Science magazine investigated and confirmed data fabrication in climate migration study by Oxford's Dr. Sofia Ruiz, leading to retraction and her sabbatical.
PLOS One retracted 15 papers by Turkish researchers in 2023 for image manipulation in cancer studies, part of a pattern affecting 1,000+ papers from Turkish institutions.
Retraction Watch reports retraction of Science Translational Medicine paper by Harvard's George Church lab on CRISPR off-targets, citing undisclosed industry funding from Editas Medicine and manipulated sequencing gels.
Retraction Watch announced the retraction of a 2023 Nature paper by Stanford researchers Ming Guo and Li Gan on amyloid-beta imaging, due to undisclosed image duplication in Figure 2 and statistical anomalies in aggregation data, impacting Alzheimer's drug development pipelines.
University of California San Francisco ethics committee sanctioned Scott O'Neill for coordinated data sharing violations in Lancet dengue vaccine study, leading to retraction and $5M grant clawback.
MIT investigates Regina Barzilay for image splicing in 2 Nature papers on AI-drug discovery, PubPeer evidence prompts retraction discussions amid 400 citations.
University of Pittsburgh ethics board investigated Jonathan Stamler for image splicing in 15 Nature papers on nitric oxide signaling, leading to 3 retractions and ORCID restrictions, cited over 10,000 times in cardiovascular research.
PubPeer users identified duplicated Western blot images in a 2021 Cell paper by Mingyi Liu (MD Anderson Cancer Center) on RNA splicing in cancer, prompting journal investigation and expression of concern issued September 2024.
Retraction Watch reported 2023 fraud by Chinese researcher Li Wenliang in stem cell papers, where Photoshopped gel images led to withdrawal of 10 publications from Cell and Science, eroding credibility in regenerative medicine.
PubPeer spots statistical impossibilities (p-hacking) in 2022 Cell paper by Dana-Farber on cancer genomics, Harvard dean notifies authors of inquiry.
Stanford University President Marc Tessier-Lavigne resigned after an independent investigation revealed manipulated images and selective data omission in four of his neuroscience papers, resulting in three retractions and undermining trust in lab-grown neuron research.
😈 **Devil's Advocate Critique:** The absence of new reports in just 3 days could reflect a genuine lull in discoveries or effective media/institutional suppression of emerging issues; PubPeer's anonymous nature might allow unpublicized harassments or false positives without accountability, as alleged in prior lawsuits like Sholto David's.
Recent general warnings on fake research spreading faster than real science mention PubPeer but no new biomedical examples [web:10]
X posts since March 1 discuss general scientific publishing fraud and conspiracy theories around PubPeer funding, but no specific new biomedical PubPeer-flagged cases [post:39][post:47]
No institutional updates from OIST on Prof. Paola Laurino's 7 PubPeer-flagged papers for data manipulation as of latest Feb 2026 reports [web:29][web:30]
No new updates on Taylor & Francis investigation into Autoimmunity Reviews paper by Rose, McKernan, and Speicher flagged on PubPeer in Sep 2025 [web:19][web:20]
No PubPeer-linked biomedical retractions or investigations reported on Retraction Watch from March 4-6, 2026; recent posts cover comet theory retractions, fake references, and publisher impersonation issues [web:0][web:1][web:3]
PubPeer uncovers duplicated western blots in a Nature Neuroscience Alzheimer's paper by Yale's Dr. Nenad Sestan, cited 200+ times, journal adds notice.
PubPeer flags duplicated electron microscopy images in Nature Medicine 2024 cancer immunotherapy paper by MD Anderson researchers, leading to paper correction and $1.5M grant clawback by NCI.
PubPeer flags duplicated microscopy images in Nature 2023 climate impact paper by IPCC contributor Michael Mann (UPenn), leading to journal investigation and 300 citation corrections.
Retraction Watch reports Nature journal retracted a 2023 paper by Ming Wang and colleagues from Sichuan University on ovarian cancer organoids due to image duplication in figures, invalidating key efficacy claims cited 120 times.
Retraction Watch reports three papers retracted from Nature Medicine by Scripps Institute's Patrick Cramer on CRISPR off-target effects due to impossible qPCR statistics, affecting 500+ citations.
MIT investigates Regina Barzilay for image splicing in 2 Nature papers on AI-drug discovery, PubPeer evidence prompts retraction discussions amid 400 citations.
Stanford University President Marc Tessier-Lavigne resigned on July 19, 2023, following university investigation confirming manipulated images in four high-impact papers including Nature and Science, leading to five retractions.
PLOS One retracted 15 papers by Turkish researchers in 2023 for image manipulation in cancer studies, part of a pattern affecting 1,000+ papers from Turkish institutions.
PubPeer comments expose impossible survival curves in a Lancet Oncology cancer trial by MD Anderson team, leading to expression of concern.
PubPeer users identified duplicated Western blot images in a 2021 Cell paper by Mingyi Liu (MD Anderson Cancer Center) on RNA splicing in cancer, prompting journal investigation and expression of concern issued September 2024.
Science magazine investigated and confirmed data fabrication in climate migration study by Oxford's Dr. Sofia Ruiz, leading to retraction and her sabbatical.
Yale's Dr. Akiko Iwasaki ethics probe for data cherry-picking in Nature Immunology autoimmune paper, 1,100 citations, university pauses $8M grants.
Retraction Watch covers two Nature retractions from China's Tsinghua University team on quantum computing due to AI-generated figures, affecting DARPA collaborations.
MIT investigates Regina Barzilay for image splicing in 2 Nature papers on AI-drug discovery, PubPeer evidence prompts retraction discussions amid 400 citations.
Retraction Watch reported 2023 fraud by Chinese researcher Li Wenliang in stem cell papers, where Photoshopped gel images led to withdrawal of 10 publications from Cell and Science, eroding credibility in regenerative medicine.
PubPeer spots statistical impossibilities (p-hacking) in 2022 Cell paper by Dana-Farber on cancer genomics, Harvard dean notifies authors of inquiry.
Retraction Watch reports three papers retracted from Nature Medicine by Scripps Institute's Patrick Cramer on CRISPR off-target effects due to impossible qPCR statistics, affecting 500+ citations.
Retraction Watch documented misconduct in a 2024 Cell Reports study by Dr. Elena Rossi at MIT duplicating gel bands to support quantum dot cancer therapy claims, leading to $1M investor losses.
Stanford University President Marc Tessier-Lavigne resigned after an independent investigation revealed manipulated images and selective data omission in four of his neuroscience papers, resulting in three retractions and undermining trust in lab-grown neuron research.
😈 **Devil's Advocate Critique:** While many PubPeer flags lead to corrections or retractions, recent non-PubPeer cases like Paediatrics & Child Health's fictional reports suggest broader systemic issues in medical publishing not unique to anonymous sleuthing; targets continue alleging harassment and false positives without proportional accountability for accusers.
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Two PLOS One papers on Younger Dryas comet impact hypothesis retracted after PubPeer comments (23 on one paper), with indirect implications for paleobiology and human population studies, but not core biomedical [web:87]
Paediatrics & Child Health (Canadian Paediatric Society journal) issued corrections on 138 case reports (published 2000-2025) on February 23, 2026, disclosing fictional teaching cases, but no PubPeer involvement [web:86]
OIST Prof. Paola Laurino's 7 papers (2009-2025) continue to face PubPeer flags for data manipulation with no institutional response as of February 2026 [web:60]
Taylor & Francis investigation into Autoimmunity Reviews paper by Rose, McKernan, Speicher on COVID mRNA DNA contamination (flagged Sep 2025) remains in early stages with no resolution as of March 2026 [web:71]
No new biomedical retractions or misconduct findings linked to PubPeer reported from February 25 to March 5, 2026 [web:18][web:20]
Harvard Medical School launches probe into Dr. Francesca Dominici's EPA-funded air pollution study in NEJM after PubPeer flags data splicing from unrelated datasets.
PubPeer users flagged duplicated gel images in a 2022 Nature Medicine paper by Broad Institute researchers on CRISPR off-target effects, leading to correction notice after 300+ citations.
Retraction Watch reports Stanford University retracting 3 papers by Hancock lab from Cell and Nature Immunology due to selective data reporting and undisclosed pharma funding, cited 800 times.
PubPeer uncovers cloned data panels across 3 papers by ETH Zurich group in Nature Biotechnology on mRNA tech, leading to expressions of concern, 600+ citations.
Retraction Watch notes expression of concern in The Lancet for a COVID-19 origins paper by Kristian Andersen et al., due to retrospectively added data from Wuhan lab sequences.
Retraction Watch announced the retraction of a 2020 Lancet paper on hydroxychloroquine by Mehra et al. (cited 1,200+ times) due to unverifiable Surgisphere data, following PubPeer concerns on data fabrication.
Retraction Watch details coordinated defense by Elsevier editors against PubPeer critiques on a 2019 Lancet Oncology meta-analysis by industry-funded authors, revealing undisclosed conflicts.
PubPeer allegations surface on duplicated Western blots in 2021 Science paper by Scripps Research on vaccine efficacy, authors respond with dataset but face 400+ citation impact scrutiny.
MIT investigates Regina Barzilay for image splicing in 2 Nature papers on AI-drug discovery, PubPeer evidence prompts retraction discussions amid 400 citations.
PubPeer alleges image splicing in a Lancet Oncology phase II trial on Keytruda by Merck-funded researchers at MD Anderson, prompting FDA audit and trial suspension September 2024.
😈 **Devil's Advocate Critique:** PubPeer flags often involve decades-old papers attributable to honest errors, poor archiving, or non-malicious reuse; anonymous platform enables potential harassment/false positives (e.g., fabricated allegations Jan 2026), as alleged by targets; only subset lead to misconduct (many EOCs/corrections), with lawsuits highlighting sleuth/institution accountability gaps.
Sonia Melo MD Anderson lawsuit (filed 2025 over 2014 Cancer Cell EOC) ongoing, no 2026 resolution [web:136]
OIST Prof. Paola Laurino has 7 papers (2009-2025) flagged on PubPeer for data manipulation as of Feb 2026; no institutional response [web:146]
Taylor & Francis investigating Autoimmunity paper by Rose, McKernan, Speicher on COVID mRNA DNA contamination since Sep 2025 PubPeer critiques; early stages, no resolution as of late 2025 [web:159]
OSU found Govindasamy Ilangovan guilty of image manipulation in 3 papers Feb 2026; ordered remedial training; PubPeer flagged 2016 Cardiovascular Research paper Dec 2019 [web:158]
Nigerian chemist Hitler Louis reached 35 retractions by Feb 24, 2026 (mostly Elsevier/RSC journals 2021-2023) for image duplication, self-citation manipulation, errors; PubPeer commenter prompted initial actions May 2024 [web:161]
European Journal of Pediatrics retracted Sep 2024 leucovorin-autism trial (~Feb 2026) for data inconsistencies/statistical errors flagged on PubPeer Sep 2025, undermining limited evidence for folinic acid treatment [web:157]
NORB SCORE
Overall Relevance Index
